Table Of Content
- Related Procedures
- What Results Can I Expect from Platelet Rich Plasma Hair Treatment?
- What is the average recovery associated with PRP injections for hair loss?
- Harvard Health Ad Watch: New drug, old song, clever tagline
- Post-surgical Healing
- What can someone expect from the results of PRP injections for hair loss?
Men and women with androgenic alopecia, a genetic condition that’s characterized by a receding hairline and the gradual disappearance of hair along the front of the scalp and top of the head, also respond well to this treatment. Though PRP to treat hair loss is relatively new, research has been promising. A small study published in the April–June 2014 issue of the Journal of Cutaneous and Aesthetic Surgery tested PRP on 11 men with androgenetic alopecia who had not had success after six months of medication. After three months, they received four treatments and saw their hair count increase by about 30 percent. Doctors began using PRP in dermatology after researchers found that high concentrations of platelets in plasma cells help promote hair growth by prolonging the growing phase of the hair cycle.
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At this point, without a standardized protocol for injections, the authors explain, it is difficult to conclude that the treatment is effective. Doctors have also used PRP to treat injuries to the tendons, muscles, and ligaments, such as those that people sustain during sporting activities. To produce PRP, a medical professional will take a blood sample and put it into a machine called a centrifuge.
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What Results Can I Expect from Platelet Rich Plasma Hair Treatment?
It works by drawing blood, processing it, then injecting it into the affected area. People with autoimmune conditions are not good candidates for PRP therapy, as the injections may trigger an overactive immune response that can lead to swollen lymph nodes, fever, or joint pain. PRP therapy should only be performed by a board-certified dermatologist or plastic surgeon with the training and expertise to perform the procedure safely. Most people can resume their normal activities almost immediately after having a PRP injection.
What is the average recovery associated with PRP injections for hair loss?
Angiogenesis and increased vascularization of the follicle are thought to be critical for the initiation of the anagen phase (Mecklenburg et al., 2000). Conversely, reduced blood flow and oxygen pressure have been observed in AGA (Goldman et al., 1996). The growth factors in PRP act on stem cells found in the bulge area of follicles, resulting in neovascularization and folliculogenesis (Li et al., 2012a, Li et al., 2012b, Takikawa et al., 2011). Increased β-catenin expression, which is believed to increase DP cell proliferation, survival, and angiogenesis was also observed (Li et al., 2012b).
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In a 2015 study of 20 people, researchers found that only 4 participants reported hair loss 12 months after their last treatment. Before treatment, all our patients (100%) had a positive hair pull test with mean number of 10 hair. After the fourth session, the pull test was negative in 9 patients (81.81%) with average number of three hairs. A significant reduction in hair loss was observed between first and fourth injection as noticed by patients. Global pictures also revealed a moderate improvement in hair volume and coverage. [Figures [Figures33 and and4]4] Hair count depicted average number of 71 hair follicular units over marked area before starting the treatment, and after 4 sessions of PRP, average number of follicular units was 93.09 follicular units.
Platelet-rich plasma (PRP) is the platelet and leukocyte-containing plasmatic fraction of anticoagulated autologous blood. While evidence supporting the clinical use of PRP in dentistry is low, PRP is widely used in sports medicine, orthopedics, and dermatology. Its beneficial activity is commonly attributed to the growth factors released from platelets accumulating in PRP; however, evidence is indirect and not comprehensive. There is thus a demand to revisit PRP with respect to basic and translational science.
Post-surgical Healing
This is due to the fact that expression of 5α-reductase and androgen receptors in female hair follicles are approximately half the levels of the male counterpart. Additionally, female hair follicles express higher levels of aromatase compared to male hair follicles, resulting in increased local production of estradiol from testosterone and subsequent less formation of DHT [4,21]. After creating platelet-rich plasma from a patient’s blood sample, that solution is injected into the target area, such as an injured knee or a tendon.
What can someone expect from the results of PRP injections for hair loss?
As to hair diameter, it was found significantly increased in 4 studies [55,56,57,58]. In particular, improvement in hair diameter achieved after combination treatment of NA-L-PRP +PRDN was more pronounced than improvement in hair count [55]. Possible side effects following a PRP injections for hair loss procedure include minimal pain, pinpoint bleeding, rendess, full, tight sensations in the scalp, and headache. PRP has a well-documented history of success in the fields of reconstructive surgery, orthopedics, dentistry, oral surgery, and facial rejuvenation.
Alopecia Areata
In contrast, higher concentrations of platelets were suggested to decrease the angiogenic potential (Giusti et al., 2009). The optimal number of treatments and time spaced between them has not been established. Establishing the significance of these elements is crucial to identify the most effective preparation for AGA.
Injections should be spaced out in the thinning area, which is typically along the hairline, part, vertex, and crown of the scalp. Treatment intervals should include monthly sessions for the first 3 months, then every 3 months for the first year (6 treatment sessions in first year at months 1, 2, 3, 6, 9, and 12). However, three monthly sessions followed by sessions at 6-month intervals have also been effective. Overall, male and female patients have had positive results from PRP injections in AGA in terms of regrowth, increased hair density, and improved quality of life (Figs. 1 and and22).
Although there have been many studies supporting the use of PRP in AGA, there have also been studies showing a lack of improvement with PRP. Puig et al. (2016) conducted a double-blind, multicenter, placebo-controlled study of 26 female patients with Ludwig II AGA. After receiving one PRP or normal saline placebo subcutaneous scalp injection, an evaluation was performed using hair count (through photography), hair mass index (Cohen hair check system), and patient opinion surveys at 26 weeks. There was no statistically significant difference in hair mass index or hair count when comparing the PRP-treated and placebo groups. However, 13.3% of PRP-treated patients reported an improvement in ease of styling, hair loss, and hair thickness compared with 0% in the placebo group (Puig et al., 2016).
Combination treatment of PRP+ polydeoxirybonucleotide (PRDR) injections resulted in a greater increase in hair count compared to PRDN injections only. On the other hand, improvement in hair count after u-PRP was found to be milder than the one achieved after treatment with topical minoxidil [60]. Hair loss and thinning affect men and women alike, often negatively impacting their confidence and self-esteem. Although treatments to regrow lost hair are available, many are invasive or problematic in other ways. Prescription medications for hair loss and thinning can cause unpleasant side effects, while a hair transplant is a costly surgical procedure that has a lengthy recovery time.
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